|
KMID : 0616120100410020115
|
|
Korean Journal of Pharmacognosy
2010 Volume.41 No. 2 p.115 ~ p.121
|
|
|
Activation of Innate Immunity by Lepiota procera Enhances Antitumor Activity
|
|
Kim Doh-Hee
Lee Seog-Won
Yoon Taek-Joon
Jo Sun-Young
Han Kyung-Hoon
Song Kwan-Yong
Lee Kye-Heui
|
|
|
Abstract
|
|
|
|
The present study was designed to explore an immunostimulating activity of crude extracts of Macrolepiota procera, and a combination therapy of cisplatin and Macrolepiota procera extracts which can potentiate the anti-cancer activity of cisplatin. For these, water extraction of Macrolepiota procera were performed at 4oC(MPE-4) and 100oC(MPE-100). In experimental metastasis of colon26-M3.1 cells, prophylactic intravenous administration of MPE (80-2,000 mg/mouse) inhibited tumor metastasis compared with tumor control. Peritoneal macrophages stimulated with MPE produced IL-12 as well as induced tumoricidal activity. In an analysis of NK-cell activity, i.v. administration of MPE (200 mg/mouse) significantly augmented NK cytotoxicity to YAC-1 tumor cells. The combination treatments of cisplatin (20 mg) and MPE (100 mg) exhibited prolongation of lifespan in colon26-M3.1 tumor bearing mouse. These results suggested that MPE stimulate immune system non-specifically and application as adjuvant in cancer treatment.
|
|
|
KEYWORD
|
|
|
Macrolepiota procera, macrophage, NK-cell, metastasis, synergistic activity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|